PIPC Chairman Tony Coelho articulated the strong support of patient groups for PCORI’s patient-centered directives. He also warned of the lingering opposition to PCORI’s patient-centered infrastructure. The patient representatives at the roundtable agreed that they strongly supported conducting comparative clinical effectiveness research directed by patient needs, outcomes and preferences during the Affordable Care Act debate. Therefore, PCORI must be identified by patients, patient groups, caregivers and providers as a critical part of the healthcare system in order to succeed. A strong evaluation framework should validate to patients that PCORI takes patient engagement seriously, and intends to measure its use and its impact both within PCORI, and outside PCORI.